Antimicrobial peptide MPX alleviates the lethal attack of Escherichia coli in mice

Escherichia coli is an important zoonotic pathogen causing intestinal diseases. In recent years, due to the unreasonable use of antibiotics, drug resistance bacteria has been increasing, and proportion multi-drug resistant strains also rising, which directly threatens health animals humans. The antimicrobial peptide MPX was isolated from wasp venom had better antibacterial activity against Gram-positive Gram-negative bacteria. Studies have found that bactericidal E. in vitro. However, whether mice still unknown. This study infected lost appetite, diarrhea, grouping together, while treatment significantly alleviated these symptoms. autopsy results congestion, bleeding, thinning wall, yellow viscous fluid cavity, congestion lungs, necrosis liver, bleeding spleen, effectively relieved above qRT-PCR could increase mRNA expression protein TFF3 jejunum colon reduce Remlβ REG3γ colon. H&E staining further alleviate pathological damage mouse intestines organs caused by infection. show good infection mice, providing essential reference for screening drugs clinical